Life Sciences

Photonic Instruments is the market leading supplier and product innovator of fluorescence excitation, illumination, and ablation systems for confocal and wide field microscopy in the life sciences.  Its systems are critical tools for life science research in the areas of drug and biomarker discovery, toxicity study, and disease state validation that rely on live cell imaging and analysis.

With the Mosaic Digital Illumination System, it is possible to simultaneously and precisely excite multiple regions of interest with complex geometries in real time and with zero delta acquisition time - realizing true digital illumination.  The Mosaic may be multiplexed with a Computer Controlled MicroPoint Laser Illumination and Ablation System for applications requiring both ablation and digital illumination.

Movie Gallery

The following gallery of movies demonstrates the depth and breadth of life science applications addressed with the MicroPoint and Mosaic systems.

Ablation
Micro-surgical cell membrane cut
Cell wounding

FRAP
Simultaneous FRAP of complex shapes
High speed FRAP kinetics
FRAP in C.Elegans

Photoactivation
Diffraction limited photoactivation with TIRF
GFP photoactivation kinetics
Simultaneous photoactivation of complex shapes
GAG-GFP photoactivation for particle tracking
Compartmentalized dynamics
Photoactivation in C.elegans

Uncaging
Calcium release

Thrombosis
Laser induced thrombosis

The Mosaic’s proprietary digital illumination technology is a robust and flexible platform amenable for OEMs to develop other fluorescence imaging applications in the life sciences such as High Content Screening, in-vivo and ex-vivo tissue and small animal imaging, biosensors, spectroscopy and microendoscopy.